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KMID : 1146920210510050571
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Journal of Pharmaceutical Investigation
2021 Volume.51 No. 5 p.571 ~ p.577
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Dissolving microneedle arrays that compensated for skin water loss due to microporation
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Kitsongsermthon Jutarat
Kumboonlert Natcha
Saksumolrat Naowarat
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Abstract
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Purpose: The stratum corneum is an important skin barrier that prevents the loss of water from the skin and protects the body from exogenous substances, such as chemicals and microbes. A microneedle array, which contains abundant micron-sized needles, can enhance the skin permeation of pharmaceutical or cosmetic active compounds by creating micropores through the epidermis and dermis. However, these micropores also cause the loss of water from the skin. Thus, our concept was to develop a dissolving microneedle (DMN) array that consisted of water-holding materials to compensate for the water loss induced by micropore formation.
Methods: DMN arrays were prepared from collagen or sodium hyaluronate (HYA) and polyvinyl alcohol (PVA) and then evaluated for their insertion potential, dissolution, ex vivo skin hydration and transepidermal water loss (TEWL).
Results: DMN arrays with HYA and PVA, at various ratios, provided sufficient mechanical strength to penetrate through the skin and dissolved in the skin within 10 min. These arrays also increased skin hydration for a few hours after they had been removed, and the TEWL was less than that from other microneedle arrays.
Conclusion: Our DMN arrays with HYA and PVA had a moisturizing effect on the skin.
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KEYWORD
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Sodium hyaluronate, Collagen, Skin hydration, Transepidermal water loss, Corneometer®, Tewameter®
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